Major Symposia
Saturday, May 4, 2024 8:00 AM – 11:30 AM Skyline Ballroom W375C
Major Symposium A
Incorporating Time and Space into Multi-omic Systems Immunology Analyses
Chairs
Ronald N. Germain, NIAID, NIH, USA
M. Virginia Pascual, Weill Cornell Med., USA
Speakers
M. Virginia Pascual, Weill Cornell Med., USA, Extra-follicular T and B cells in juvenile autoimmune disease
Karin Pelka, UCSF, USA, Spatially organized immune hubs in colon cancer
Sam M. Murray, Univ. of Oxford, GBR, Multi-omic immunophenotyping to identify predictors of mRNA vaccine responsiveness in immunocompromised individuals
Donna L. Farber, Columbia Univ., USA, Tissue and age determinants for human immune response
Zena Marie Del Mundo, Univ. of California, Irvine, USA, Unique populations of pituitary macrophages regulate reproductive hormone secretion
Ronald N. Germain, NIAID, NIH, USA, Probing immune system function in situ using multiplex 2D and 3D imaging and new analytical tools
Nir Hacohen, Broad Inst. of MIT and Harvard, USA, Organization of the immune response in tumors
Saturday, May 4, 2024 8:00 AM – 11:30 AM Skyline Ballroom W375D
Major Symposium B
Recent Breakthroughs and Emerging Therapeutic Strategies for Chronic Inflammatory and Fibrotic Diseases
Chairs
Thomas A. Wynn, Pfizer
Joanne L. Viney, Seismic Therapeut.
Speakers
Thomas A. Wynn, Pfizer, In pursuit of transformational efficacy for autoimmune, inflammatory, and fibrotic diseases with multi-functional therapeutics
Emma Guttman-Yassky, Icahn Sch. of Med., Mount Sinai, USA, A translational approach to improve therapeutics in atopic dermatitis and beyond
Diandra A. Ellis, Tulane Univ., USA, Chitinase 3-Like-1/BRP-39 regulates extracellular matrix remodeling during allergic fungal asthma
Shelia M. Violette, Q32 Bio, Tissue targeted regulators of complement in disease: rationale and novel strategies
Tania E. Velez, Univ. of Virginia, USA, Expanded GATA3+ T regulatory cells fail to control germinal center responses during pulmonary fibrosis in humans and mice
Qizhi Tang, UCSF, USA, Engineering next-gen Tregs for type 1 diabetes
Joanne L. Viney, Seismic Therapeut., The polypharmacology of dual cell bidirectional (DcB) agonist antibodies for treating autoimmunity
Sunday, May 5, 2024 8:00 AM – 11:30 AM Skyline Ballroom W375C
Major Symposium C
Unleashing Targets for Novel Cancer Immunotherapies: Beyond T Cell Checkpoints
Chairs
José R. Conejo-Garcia, Duke Univ. Sch. of Med., USA
Paulo C. Rodriguez, Moffitt Cancer Ctr., USA
Speakers
Tyler I. Curiel, Dartmouth Col., USA, Cell-intrinsic PD-L1 signals as actionable cancer immunotherapy targets
José R. Conejo-Garcia, Duke Univ. Sch. of Med., USA, Harnessing coordinated humoral and cellular responses in human cancer
Sana Mir, UR Med., USA, Universally conserved signals for CAR T cell migration to solid tumors
Dmitry Gabrilovich, AstraZeneca, Myeloid cells in cancer: old challenges and new opportunities
Yating Zheng, Univ. of Michigan Med. Sch., USA, An engineered viral protein rewires signaling pathways to overcome T cell suppression
Paulo C. Rodriguez, Moffitt Cancer Ctr., USA, Strategies to restore protective immunity in cancer hosts by targeting Notch signaling
Catherine J. Wu, Dana-Farber Cancer Inst., USA, Updates on personal cancer vaccines
Sunday, May 5, 2024 8:00 AM – 11:30 AM Skyline Ballroom W375D
Major Symposium D
Great Expectations: Immunology of Pregnancy
Chairs
Sing Sing Y. Way, Cincinnati Children’s Hosp. Med. Ctr., USA
Adrian Erlebacher, UCSF, USA
Speakers
Adrian Erlebacher, UCSF, USA, Glycan regulation of fetomaternal tolerance
Anita S.F. Chong, Univ. of Chicago, USA, Allogeneic conflict in pregnancy and transplantation
Brittney Knott, Univ. of Alabama, Birmingham, USA, Critical role of NFAT in tissue residency transcriptional programming of human uterine natural killer cells
Carolyn B. Coyne, Duke Univ. Sch. of Med., USA, Antimicrobial signaling at the maternal-fetal interface
Dustyn B. Levenson, Washington Univ. Sch. of Med., St. Louis, USA, Mapping the cellular landscape of the maternal-fetal interface in women with preterm birth and chronic chorioamnionitis
Galit Alter, Ragon Inst. of MGH, MIT, and Harvard, USA, Decoding the rules of maternal-fetal antibody transfer
Sing Sing Y. Way, Cincinnati Children’s Hosp. Med. Ctr., USA, Immunology learned from mothers and babies
Monday, May 6, 2024 8:00 AM – 11:30 AM Skyline Ballroom W375C
Major Symposium E
New Insights into Thymic Selection, Tolerance, and Regeneration
Chairs
Kristin A. Hogquist, Univ. of Minnesota Med. Sch., USA
Adrian C. Hayday, King's Col. London, GBR
Speakers
Kristin , A. Hogquist, Univ. of Minnesota Med. Sch., USA, Sterile interferons activate thymic APC to promote both diversity and tolerance
Lauren I. R. Ehrlich, Univ. of Texas, Austin, USA, Homeostasis and activation of heterogeneous thymic dendritic cells are differentially regulated by distinct thymocyte subsets
Alexandra M. Hoyt-Miggelbrink, Duke Univ., USA, Developing thymocytes cue in unique subsets of neurons to support optimal thymic architecture
Jakub Abramson, Weizmann Inst. of Sci., ISR, HECking the sexual dimorphism of the immune response
Sarah A. Wedemeyer, UT Hlth. San Antonio Long Sch. of Med., USA, A dynamic paracrine FGF21-mTORC1/mTORC2 signaling axis regulates thymus function across the lifespan
James M. Gardner, UCSF, USA, Extrathymic Aire-expressing cells in immune homeostasis
Adrian C. Hayday, King's Col. London, GBR, BTNL-dependent γδ T cell selection: from murine fetal thymus to human genetic
Monday, May 6, 2024 8:00 AM – 11:30 AM Skyline Ballroom W375D
Major Symposium F
Immune Responses to Chronic Viral, Bacterial, Fungal, and Parasitic Infections
Chairs
Christina L. Stallings, Washington Univ. Sch. of Med., St. Louis, USA
Paul G. Thomas, St. Jude Children’s Res. Hosp., USA
Speakers
Christina L. Stallings, Washington Univ. Sch. of Med., St. Louis, USA, Contributions of innate immune responses to tuberculosis disease outcomes
Jakub von Moltke, Univ. of Washington, USA, Crosstalk between memory Th2 cells and epithelial tuft cells regulates protective immunity to intestinal helminth infection
Sophie E. Sipprell, Univ. of North Carolina, Charlotte, USA, Substance P augments the production of neutrophil recruiting chemokines by Staphylococcus aureus challenged osteoclasts
Boris Striepen, Univ. of Pennsylvania Sch. of Vet. Med., USA, The intestinal intracellular parasite Cryptosporidium
Rimjhim Agarwal, La Jolla Inst. for Immunol., USA, Chikungunya-virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans
Tracey J. Lamb, Univ. of Utah, USA, Defining the characteristics of pathogenic CD8+ T cells in malaria
Paul G. Thomas, St. Jude Children’s Res. Hosp., USA, Specificity matters: T cell responses to respiratory viral infections
Tuesday, May 7, 2024 8:00 AM – 11:30 AM Skyline Ballroom W375C
Major Symposium G
Sub-cellular Compartment Signaling in the Regulation of Immune Responses
Chairs
Erika L. Pearce, Johns Hopkins Univ. Sch. of Med., USA, AAI Nominating Committee Chair
Will Bailis, Children's Hosp. of Philadelphia, USA
Speakers
Marcia C. Haigis, Harvard Med. Sch., USA, Metabolites in the tumor microenvironment
Will Bailis, Children's Hosp. of Philadelphia, USA, Coordinating T cell metabolic adaptation during nutrient stress
Ronal M. Peralta, Univ. of Pittsburgh, USA, Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism
Navdeep S. Chandel, Northwestern Univ., USA, Mitochondria as signaling organelles control immunity
Cody Elkins, Emory Univ. Sch. of Med., USA, Obesity disrupts cholesterol homeostasis to specifically impair TCR-driven ST2hi VAT Treg accumulation and insulin sensitivity
Jonathan R. Brestoff, Washington Univ. Sch. of Med., St. Louis, USA, Mitochondria transfer to macrophages in metabolic diseases
Michael Karin, UCSD, USA, Mitochondrial DNA oxidation and autoimmunity
Tuesday, May 7, 2024 8:00 AM – 11:30 AM Skyline Ballroom W375D
Major Symposium H
Context Is Everything—Extrafollicular B Cell Responses: the Good and the Bad
Chairs
Frances E. Lund, Univ. of Alabama, Birmingham, USA
Nicole Baumgarth, Johns Hopkins Bloomberg Sch. of Pub. Hlth., USA
Speakers
Nicole Baumgarth, Johns Hopkins Bloomberg Sch. of Pub. Hlth., USA, Extrafollicular B cell responses—when “extra” means “outside,” not “superfluous”
Evelien M. Bunnik, UT Hlth. San Antonio, USA, Atypical B cells in the immune response to malaria
Lindsay E. Bass, Vanderbilt Univ., USA, The complex role of somatic hypermutation in supporting insulin recognition by B lymphocytes in at-risk type 1 diabetes participants
Mark J. Shlomchik, Univ. of Pittsburgh Sch. of Med., USA, Control of extrafollicular vs. germinal center responses in immunity and autoimmunity
Frances E. Lund, Univ. of Alabama, Birmingham, USA, T-bet programming of antigen experienced extrafollicular and germinal center derived B cells–roles for Type II IFN signaling in both cell fates
Jeongsoo Lee, Korea Advanced Inst. of Sci.and Technol., KOR, SARS-CoV-2-specific atypical memory B cells induced by mRNA vaccine exhibit robust effector functions
Ignacio Sanz, Emory Univ. Sch. of Med., USA, Extrafollicular responses in protective and pathogenic responses