Sunday, May 5, 2024 2:15 PM – 3:00 PM ET Exhibitor Workshop Room 2
Lineage-Ambiguous Memory T Cells Drive Early-Allergic Sensitization Through De Novo IgE Generation
Speaker
Josh Koenig, Ph.D., Assistant Professor, McMaster University, Immunology Research Centre
How IgE secretion drives food allergy remains poorly understood. Using an early-stage model of food allergy, we found that a single gavage of allergen with cholera toxin adjuvant failed to sensitize mice, but allergen re-exposure, even one year later, caused sensitization and anaphylaxis. Initial exposure induced CD44hi lineage-ambiguous CD4+ T cells but failed to activate B cells. Allergen re-exposure drove T-follicular helper cell differentiation and de novo IgE production. Our data implicate memory CD4+ T cells in initiating IgE production and holding IgE memory.
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