Tuesday, May 7, 2024     8:00 AM – 11:30 AM ET     Skyline Ballroom W375C

Major Symposium G

Sub-cellular Compartment Signaling in the Regulation of Immune Responses

Chairs
Erika L. Pearce, Johns Hopkins Univ. Sch. of Med., USA, AAI Nominating Committee Chair
Will Bailis, Children’s Hosp. of Philadelphia, USA

Speakers
Marcia C. Haigis, Harvard Med. Sch., USA, Metabolites in the tumor microenvironment
Will Bailis, Children’s Hosp. of Philadelphia, USA, Coordinating T cell metabolic adaptation during nutrient stress
Ronal M. Peralta, Univ. of Pittsburgh, USA, Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism
Navdeep S. Chandel, Northwestern Univ., USA, Mitochondria as signaling organelles control immunity
Cody Elkins, Emory Univ. Sch. of Med., USA, Obesity disrupts cholesterol homeostasis to specifically impair TCR-driven ST2hi VAT Treg accumulation and insulin sensitivity
Jonathan R. Brestoff, Washington Univ. Sch. of Med., St. Louis, USA, Mitochondria transfer to macrophages in metabolic diseases
Michael Karin, UCSD, USA, Mitochondrial DNA oxidation and autoimmunity